Synthesis, Spectral Characterization, Docking Studies and QSAR Screening of 4-amino-benzenesulfonamides/N-acetyl 4-amino-benzenesulfonamide Derivatives as Antimicrobial Agents

Synthesis, molecular docking and QSAR studies of 2, 4-disubstituted thiazoles as antimicrobial agents

Article history: Received on: 13/11/2014 Revised on: 04/12/2014 Accepted on: 22/01/2015 Available online: 27/02/2015 In present study a series of 2,4-disubstituted thiazole derivatives was synthesized and evaluated for their in vitro antibacterial and antifungal activities against B. subtilis, E. coli, S. aureus, C. albicans and A. niger by tube dilution method. The analysis of antimicrobial ac...

Synthesis and Spectral Studies on Thorium (IV) Coordination Compounds of 4-[N-(2-Hydroxybenzalidene)amino] AntipyrineSmeicarbazone and 4-[N-Cinnamalidene) amino] ANtipyrine Semicarbazone

The stereochemistry of the actinide elements has recently undergone considerable development and a wide variety of coordination numbers and geometries have been observed. This structural versatility arises from the lack of strong crystal field effects for the 5f-electronic configurations as well as from the large ionic radii of these metal ions, which change markedly with oxidation number, ...

synthesis and docking studies of new 4-oxo-1,3-thiazolidine derivatives as potential anticonvulsant agents

Synthesis of Some 4-Thiazolidinone Derivatives as Antitubercular Agents

Substituted Schiff's bases 2a-o prepared by the treatment of 2-amino-4-(?-methoxyiminocarbomethoxymethyl)-thiazole 1 with different aromatic aldehydes, on cyclocondensation with mercaptoaceticacid and mercaptopropionicacid in dry benzene furnished desired thiazolidinones of type 3a-o and 4a-j, respectively. The structure of the compounds have been assigned on the basis of elemental analyses and...

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

The antileishmanial activity of a series of bis-pyridinium derivatives that are analogues of pentamidine have been investigated, and all compounds assayed were found to display activity against promastigotes and intracellular amastigotes of Leishmania donovani and Leishmania major, with 50% effective concentrations (EC50s) lower than 1 μM in most cases. The majority of compounds showed similar ...